diff --git a/python/bindings/bind_oot_file.py b/python/bindings/bind_oot_file.py
index 91719f7..06bd614 100644
--- a/python/bindings/bind_oot_file.py
+++ b/python/bindings/bind_oot_file.py
@@ -37,7 +37,7 @@ args = parser.parse_args()
 
 prefix = args.prefix
 output_dir = args.output_dir
-defines = tuple(','.join(args.defines).split(','))
+defines = tuple([d for d in ','.join(args.defines).split(',') if d])
 includes = ','.join(args.include)
 name = args.module